Notes from NEET topper
Significance of the Krebs Cycle:
The Krebs cycle is of great significance in cellular respiration and metabolism for several reasons:
-
Energy Production: It generates high-energy molecules, such as NADH and FADH2, which carry electrons to the electron transport chain (ETC). The ETC uses these electrons to produce ATP, the primary energy currency of the cell.
-
Carbon Skeletons: The Krebs cycle breaks down acetyl-CoA, releasing carbon dioxide and providing carbon skeletons for biosynthesis. These intermediates are used in the synthesis of amino acids, fatty acids, and other molecules needed for cell growth and maintenance.
-
Redox Reactions: The cycle is involved in redox reactions that transfer electrons from acetyl-CoA to electron carriers (NADH and FADH2). These carriers play a vital role in oxidative phosphorylation, where ATP is generated.
-
Oxidation of Acetyl-CoA: The Krebs cycle serves as the final pathway for the complete oxidation of acetyl-CoA derived from glucose, fatty acids, and amino acids. It ensures that the energy stored in these molecules is maximally extracted.
